Table 3 The Kinase target networks of the MMP family in HNSC
MMP | Enriched kinase target | Description | Leading EdgeNum | P value |
|---|---|---|---|---|
MMP1 | CDK2 | Cyclin dependent kinase 2 | 99 | 0.000 |
ATM | ATM serine/threonine kinase | 51 | 0.000 | |
MMP2 | ATR | ATR serine/threonine kinase | 28 | 0.000 |
NEK2 | NIMA related kinase 2 | 5 | 0.000 | |
MMP3 | ROCK1 | Rho associated coiled-coil containing protein kinase 1 | 19 | 0.000 |
ATR | ATR serine/threonine kinase | 34 | 0.000 | |
ILF3 | ATR | ATR serine/threonine kinase | 33 | 0.000 |
PLK1 | Polo like kinase 1 | 33 | 0.000 | |
MMP7 | MAP3K5 | Mitogen-activated protein kinase kinase kinase 5 | 7 | 0.000 |
PKN2 | Protein kinase N2 | 7 | 0.000 | |
MMP8 | CDK5 | Cyclin dependent kinase 5 | 30 | 0.002 |
NTRK1 | Neurotrophic receptor tyrosine kinase 1 | 7 | 0.003 | |
MMP9 | ATM | ATM serine/threonine kinase | 53 | 0.000 |
ATR | ATR serine/threonine kinase | 32 | 0.000 | |
MMP10 | ROCK1 | Rho associated coiled-coil containing protein kinase 1 | 23 | 0.011 |
ATM | ATM serine/threonine kinase | 45 | 0.000 | |
MMP11 | ATR | ATR serine/threonine kinase | 33 | 0.000 |
AURKB | Aurora kinase B | 32 | 0.000 | |
MMP12 | LYN | LYN proto-oncogene, Src family tyrosine kinase | 20 | 0.000 |
SYK | Spleen associated tyrosine kinase | 14 | 0.000 | |
MMP13 | ATM | ATM serine/threonine kinase | 37 | 0.000 |
ATR | ATR serine/threonine kinase | 33 | 0.000 | |
MMP14 | PRKCG | Protein kinase C gamma | 11 | 0.000 |
ROCK1 | Rho associated coiled-coil containing protein kinase 1 | 18 | 0.000 | |
MMP15 | CDK1 | Cyclin dependent kinase 1 | 79 | 0.000 |
ATR | ATR serine/threonine kinase | 21 | 0.000 | |
MMP16 | FYN | FYN proto-oncogene, Src family tyrosine kinase | 31 | 0.019 |
CDK5 | Cyclin dependent kinase 5 | 25 | 0.000 | |
MMP17 | ATM | ATM serine/threonine kinase | 49 | 0.000 |
ATR | ATR serine/threonine kinase | 35 | 0.000 | |
MMP19 | MAP2K4 | Mitogen-activated protein kinase kinase 4 | 4 | 0.000 |
LYN | LYN proto-oncogene, Src family tyrosine kinase | 20 | 0.000 | |
MMP20 | PKN2 | Protein kinase N2 | 6 | 0.000 |
ZAP70 | Zeta chain of T-cell receptor associated protein kinase 70 | 8 | 0.000 | |
MMP21 | GRK4 | G protein-coupled receptor kinase 4 | 2 | 0.007 |
MKNK2 | MAP kinase interacting serine/threonine kinase 2 | 3 | 0.035 | |
MMP23B | ATM | ATM serine/threonine kinase | 57 | 0.000 |
MAP3K8 | Mitogen-activated protein kinase kinase kinase 8 | 11 | 0.000 | |
MMP24 | CDK1 | Cyclin dependent kinase 1 | 108 | 0.000 |
ATM | ATM serine/threonine kinase | 56 | 0.000 | |
MMP25 | FYN | FYN proto-oncogene, Src family tyrosine kinase | 21 | 0.000 |
SYK | Spleen associated tyrosine kinase | 16 | 0.000 | |
MMP26 | LCK | LCK proto-oncogene, Src family tyrosine kinase | 28 | 0.000 |
JAK2 | Janus kinase 2 | 11 | 0.011 | |
MMP27 | CHEK1 | Checkpoint kinase 1 | 48 | 0.000 |
PLK1 | Polo-like kinase 1 | 34 | 0.000 | |
MMP28 | LCK | LCK proto-oncogene, Src family tyrosine kinase | 21 | 0.000 |
PRKD1 | Protein kinase D1 | 10 | 0.000 |