Immune profiling and prognostic model of pancreatic cancer using quantitative pathology and single-cell RNA sequencing

Table 2 Univariable and multivariable cox regression analysis of prognostic features

Features	UniCox		P_value	MultiCox_model 1		P_value	MultiCox_model 2		P_value
Features	HR	95% CI	P_value	HR	95% CI	P_value	HR	95% CI	P_value
P_sc	5.466	1.302–22.938	0.02	8.340	1.771–39.281	0.007	9.257	10.435–82121.170	0.003
P_sa	7.823	0.682–89.723	0.098				3.073	1.804E-07–0.523	0.033
D_cd8	1.239	1.048–1.464	0.012
D_pd1	1.152	1.000–1.327	0.049				5.069	0.300–0.856	0.011
D_cd68	1.071	0.901–1.274	0.435
P_topdl1	1.015	0.828–1.245	0.883				7.710	0.565–1.053	0.102
P_tupdl1	0.992	0.850–1.158	0.92
P_spdl1	1.077	0.865–1.340	0.508
D_cd8_pd1	1.158	1.021–1.313	0.023
D_pdl1_30_pd1	1.152	1.004–1.322	0.044
D_tu_30_im	1.065	0.904–1.254	0.453
D_tu_30_cd8	1.182	1.003–1.393	0.046
D_tu_30_cd68	1.021	0.899–1.161	0.746
D_pdl1_50_pd1	1.163	1.010–1.339	0.035				2.136	1.216–3.753	0.008
D_tu_50_im	1.099	0.929–1.301	0.271
D_tu_50_cd8	1.217	1.034–1.432	0.018	1.268	1.072–1.49	0.006	1.278	1.028–1.587	0.027
D_tu_50_cd68	1.037	0.911–1.180	0.58

The bold P value means P < 0.05 with significantly statistical difference
UniCox, Univariable Cox regression, MultiCox, Multivariable Cox regression; HR, hazard ratio, CI confidence interval. Model 1: variables with P_value < 0.05 were used; Model 2: all variables were used

ISSN: 1479-5876