Fig. 6

ScRNA-seq delineates the cellular landscape of PDAC and adjacent noncancerous tissues. A–C t-SNE plot showing original cell clusters (A), renamed cell types (B), specimens derived information in PDAC (C). Each dot represented one cell, and cell types were coded with different colors. D–F t-SNE plot showing the cellular landscape of adjacent noncancerous tissues. G–H Dot plots showing top 5 cell types-specific genes. Size of dots indicated the proportion of cells expressing the selected genes, and intensity of color (from white to purple) indicated the average expression level. I The box plots showing the proportion of cell types in PDAC and the counterpart tissues. For pie charts, the proportion of stromal cells (green) was showed. J The differences in the proportion of positive cells expressing immune marker between PDAC and adjacent noncancerous tissues