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Table 5 Mediation analysis for BMI and NAFLD via lipid parameters in the whole population stratified by BMI

From: Lipid metabolism, BMI and the risk of nonalcoholic fatty liver disease in the general population: evidence from a mediation analysis

Mediator

Total effect

Mediation effect

Direct effect

PM (%)

P-value of PM

BMI < 18.5 kg/m2 (n = 1545)

 TC

− 0.000 (− 0.004, 0.003)

0.000 (− 0.000, 0.000)

− 0.001 (− 0.004, 0.003)

–

0.912

 TG

− 0.000 (− 0.004, 0.003)

0.000 (− 0.000, 0.000)

− 0.001 (− 0.004, 0.003)

–

0.878

 HDL-C

− 0.000 (− 0.004, 0.003)

− 0.000 (− 0.000, 0.000)

− 0.000 (− 0.004, 0.003)

–

0.910

 LDL-C

− 0.000 (− 0.004, 0.003)

0.000 (− 0.000, 0.000)

− 0.001 (− 0.004, 0.003)

–

0.878

 Non-HDL-C

− 0.000 (− 0.004, 0.003)

0.000 (− 0.000, 0.000)

− 0.001 (− 0.004, 0.003)

–

0.858

 RC

− 0.000 (− 0.004, 0.003)

0.000 (− 0.000, 0.001)

− 0.001 (− 0.004, 0.003)

–

0.854

 TC/HDL-C ratio

− 0.000 (− 0.004, 0.003)

0.000 (− 0.000, 0.000)

− 0.000 (− 0.004, 0.003)

–

0.974

 TG/HDL-C ratio

− 0.000 (− 0.004, 0.003)

0.000 (− 0.000, 0.000)

− 0.000 (− 0.004, 0.003)

–

0.970

 LDL/HDL-C ratio

− 0.000 (− 0.004, 0.003)

0.000 (− 0.000, 0.000)

− 0.000 (− 0.004, 0.003)

–

0.966

 Non-HDL-C/HDL-C ratio

− 0.000 (− 0.004, 0.003)

0.000 (− 0.000, 0.000)

− 0.000 (− 0.004, 0.003)

–

0.974

 RC/HDL-C ratio

− 0.000 (− 0.004, 0.003)

0.000 (− 0.000, 0.000)

− 0.000 (− 0.004, 0.003)

–

0.972

BMI: 18.5–25 kg/m2 (n = 10,442)

 TC

0.062 (0.048, 0.076)

0.001 (0.001, 0.002)

0.060 (0.046, 0.074)

2.4

< 0.001

 TG

0.062 (0.048, 0.076)

0.007 (0.005, 0.010)

0.054 (0.040, 0.068)

12.1

< 0.001

 HDL-C

0.062 (0.048, 0.076)

0.005 (0.004, 0.007)

0.057 (0.043, 0.071)

8.3

< 0.001

 LDL-C

0.062 (0.048, 0.076)

0.003 (0.002, 0.005)

0.059 (0.045, 0.073)

5.1

< 0.001

 Non-HDL-C

0.062 (0.048, 0.076)

0.005 (0.004, 0.007)

0.057 (0.043, 0.071)

8.3

< 0.001

 RC

0.062 (0.048, 0.076)

0.010 (0.008, 0.012)

0.052 (0.038, 0.066)

16.2

< 0.001

 TC/HDL-C ratio

0.062 (0.048, 0.076)

0.010 (0.008, 0.012)

0.052 (0.038, 0.066)

15.9

< 0.001

 TG/HDL-C ratio

0.062 (0.048, 0.076)

0.008 (0.005, 0.010)

0.054 (0.040, 0.068)

12.2

< 0.001

 LDL/HDL-C ratio

0.062 (0.048, 0.076)

0.009 (0.007, 0.011)

0.053 (0.039, 0.067)

13.9

< 0.001

 Non-HDL-C/HDL-C ratio

0.062 (0.048, 0.076)

0.010 (0.008, 0.012)

0.052 (0.038, 0.066)

15.9

< 0.001

 RC/HDL-C ratio

0.062 (0.048, 0.076)

0.011 (0.008, 0.013)

0.051 (0.037, 0.065)

17.2

< 0.001

BMI: ≥ 25 kg/m2 (n = 2264)

 TC

0.078 (0.045, 0.113)

0.000 (− 0.001, 0.002)

0.077 (0.045, 0.113)

–

0.826

 TG

0.077 (0.044, 0.113)

− 0.002 (− 0.009, 0.004)

0.080 (0.047, 0.113)

–

0.478

 HDL-C

0.077 (0.045, 0.111)

0.002 (− 0.003, 0.008)

0.075 (0.043, 0.110)

–

0.410

 LDL-C

0.077 (0.044, 0.113)

0.000 (− 0.001, 0.002)

0.077 (0.044, 0.112)

–

0.558

 Non-HDL-C

0.077 (0.044, 0.112)

0.001 (− 0.002, 0.004)

0.077 (0.044, 0.112)

–

0.666

 RC

0.077 (0.044, 0.113)

− 0.001(− 0.007, 0.005)

0.079 (0.046, 0.112)

–

0.712

 TC/HDL-C ratio

0.077 (0.043, 0.112)

0.001 (− 0.003, 0.007)

0.075 (0.043, 0.109)

–

0.556

 TG/HDL-C ratio

0.077 (0.043, 0.112)

− 0.002 (− 0.008, 0.005)

0.078 (0.046, 0.112)

–

0.676

 LDL/HDL-C ratio

0.077 (0.043, 0.111)

0.002 (− 0.002, 0.006)

0.075 (0.042, 0.109)

–

0.442

 Non-HDL-C/HDL-C ratio

0.077 (0.043, 0.112)

0.001 (− 0.003, 0.007)

0.075 (0.043, 0.109)

–

0.556

 RC/HDL-C ratio

0.077 (0.043, 0.112)

− 0.000 (− 0.006, 0.006)

0.077 (0.045, 0.111)

–

0.930

  1. PM: propotion mediate; other abbreviations as in Table 1
  2. Adjusting variables: sex, age, WC, SBP, DBP, ALT, AST, GGT, FPG, HbA1c, habit of exercise, smoking status and drinking status
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Journal of Translational Medicine

ISSN: 1479-5876

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