Fig. 2

Comparison of genomic landscape between the PTMETA cohort and the TCGA cohort. (a) Distribution of mutation burdens in each cohort. The mutation burden calculated from a tumor-normal pair is represented by each dot. The Wilcoxon rank-sum test was used to calculate the p-value; (b) Gene-level alteration frequencies in the PTMETA and TCGA; (c) Significantly recurrent somatic CNAs in genomic regions; (d) Mutation contributions of the signatures from de novo decomposition by the NMF algorithm and cosine correlation of the signatures with the 30 COSMIC mutational signatures (v2) from the PTMETA cohort; (e) Mutation contributions of the signatures from de novo decomposition by the NMF algorithm and cosine correlation of the signatures with the 30 COSMIC mutational signatures (v2) from TCGA cohort; (f) The proportion of mutation signatures. The Chi-square test was used to calculate the p-value, which was based on the number of mutation signatures in each cohort