Fig. 1

Glioma induces gut microbiota and related metabolites dysbiosis of mice. A Workflow of Glioma orthotopic xenograft model construction and representative bioluminescence images (BLI) of mice in model group at day 14. B The β-diversity indexes evaluated by weighted-wilcox of gut microbiota between Control and Model groups. C Taxonomic distributions of bacteria from Control and Model groups at phylum and genus level. D Differently abundant of KEGG pathways of the gut microbiota in Control and Model mice. E OPLS-DA score plot based on LC–MS ( +) (R²X = 0.242, R²Y = 0.967, Q² = 0.69) and LC–MS (-) (R2X = 0.491, R2Y = 0.801, Q2 = 0.629) data. F Volcano plots of differential metabolites with fold change > 2 and p < 0.05 based on LC–MS ( +) and LC–MS (-) between Control and Model groups