Fig. 9

Validation of the clinical significance of IMMT in ethnic Chinese BC specimens and from a bioinformatic pan-cancer perspective. A–E High IMMT expression as a pathological biomarker and a prognostic factor for poor outcome in ethnic Chinese patients with BC. Representative image and quantitative bar charts of tumor-adjacent normal tissue vs. tumor (A and B) and grade 1 vs. grade 2 vs. grade 3 tissues (C and D). Note that the non-neoplastic mammary gland duct cells and malignant mammary gland duct cells show mild and strong cytoplasmic expression of IMMT, respectively (100x) (A). The grade 1, grade 2, and grade 3 invasive ductal carcinoma cells show mild, moderate, and strong cytoplasmic expressions of IMMT, respectively (C). Kaplan–Meier curve of the overall survival (cutoff value high/low: 67%/33%) (E). F–J Generalization value of IMMT across cancers. ***p < 0.0001, **p < 0.01, *p < 0.05 between tumor and normal (F). Kaplan–Meier curve representing the association between IMMT and RFS in cervical squamous cell carcinoma (CESC) (G), liver hepatocellular carcinoma (LIHC) (H), lung squamous cell carcinoma (LUSC) (I), and uterine corpus endometrial carcinoma (UCEC) (J)