Fig. 1

Clinicopathological Screening of IMMT-centric MICOS Components in BC. A Schematic diagram depicting the MICOS subunits in mitochondria. B Single nucleotide variant (SNV) oncoplot of BC samples. The number and percentage of distinct SNVs, including missense mutation (green), nonsense mutation (red), splice site (orange), frame shift/deletion (light blue) and presence of multiple types of mutation in the same gene (Multi Hit, black) on each gene in 1,026 BC samples are indicated. Level of tumor mutation burden (TMB) in each sample is documented on the top of the oncoplot. C–H the gene expression levels of IMMT (C), CHCHD6 (D), CHCHD3 (E), APOOL (F), APOO (G), and MICOS10 (H) in normal tissues and BC tumors. I–M the protein expression levels of IMMT (I), CHCHD6 (D), CHCHD3 (E), APOOL (F), APOO (G), and MICOS10 (H) in normal tissues and BC tumors accessed from the CPTAC repository. *p < 0.05, ***p < 0.001 between the two groups. N heatmap comparing the differential gene expressions of IMMT, CHCHD6, CHCHD3, MICOS10, APOOL, and APOO between different mutation statuses. LOG FC, fold change expressed as log logarithm to the base 10. O Chord diagram illustrating the relationship between the hazard ratio in BC patients harboring high gene expressions of IMMT, CHCHD6, APOOL, APOO, and MICOS10 and survival rate. OS overall survival; DFS disease-free survival, DMFS distant metastasis free survival