Drug name | Introduction | Drug target | Drug target pathway |
---|---|---|---|
Rapamycin | Drugs that selectively target mTORC1 are expected to impair cancer metabolism and are considered promising anti-cancer therapies | MTORC1 | PI3K/MTOR signaling |
PD.0325901 | Mirdametinib (PD-0325901) is an oral, non-ATP-competitive, highly selective, and potent small-molecule inhibitor of MEK1 and MEK2 | MEK1, MEK2 | ERK MAPK signaling |
Dasatinib | Dasatinib is an orally available short-acting dual ABL/SRC tyrosine kinase inhibitor (TKI). It potently inhibits BCR-ABL and SRC family kinases (SRC, LCK, YES, FYN), but also c-KIT, PDGFR-a and PDGFR-b, and ephrin receptor kinase | ABL, SRC, Ephrins, PDGFR, KIT | RTK signaling, kinases |
MG-132 | The peptide-aldehyde proteasome inhibitor MG132 (carbobenzoxyl-l-leucyl-l-leucyl-l-leucine) induces the apoptosis of cells by a different intermediary pathway. Although the pathway of induction of apoptosis is different, it plays a crucial role in anti-tumor treatment | Proteasome, CAPN1 | Protein stability and degradation |
Cytarabine | Cytarabine (molecular formula: C9H13N3O5) interferes with DNA synthesis, acting on DNA/RNA polymerase (and other nucleotide reductase enzymes), reducing cell ability to replicate | Antimetabolite | Other |
A-443654 | A-443654, a specific Akt inhibitor, interferes with mitotic progression and bipolar spindle formation. A-443654 induces G2/M accumulation, defects in centrosome separation, and formation of either monopolar arrays or disorganized spindles | AKT1, AKT2, AKT3 | PI3K/MTOR signaling |
AZ628 | AZ628 is a hydrophobic Raf-kinase inhibitor currently in clinical trial of various cancer | BRAF | ERK MAPK signaling |
WH-4–023 | WH-4-023 is a LCK inhibitors | SRC, LCK | Other, kinases |
Mitomycin.C | Mitomycin C (MMC) is an alkylating agent with extraordinary ability to crosslink DNA, preventing DNA synthesis | DNA crosslinker | DNA replication |
TW.37 | TW-37 is a novel, potent and non-peptide Bcl-2 small-molecule inhibitor | BCL2, BCL-XL, MCL1 | Apoptosis regulation |