Constructing a novel mitochondrial-related gene signature for evaluating the tumor immune microenvironment and predicting survival in stomach adenocarcinoma

Table 3 Univariate and multivariate Cox regression analysis of various prognostic parameters in STAD patients

Variables	Patient (N = 317)	Univariate analysis		Multivariate analysis
Variables	Patient (N = 317)	HR [95% CI]	P value	HR [95% CI]	P value
Age
< 67	152	1		1
≥ 67	165	2.093[1.412, 3.103]	< 0.001	1.514[1.068, 2.146]	0.020
Gender
Male	203	1
Female	114	1.254 [0.851, 1.849]	0.253
T stage
T1	13	1
T2	68	1.642[0.347, 7.763]	0.532
T3	151	1.861[0.338, 10.249]	0.475
T4	85	1.611[0.283, 9.160]	0.591
N stage
N0	98	1
N1	83	1.453[0.729, 2.895]	0.288
N2	65	1.040[0.426, 2.537]	0.932
N3	66	1.658[0.691, 3.977]	0.257
NX	5	1.732[0.213, 14.072]	0.607
M stage
M0	286	1
M1	20	1.095[0.441, 2.717]	0.845
MX	11	1.125[0.381, 3.323]	0.832
Tumor stage
I	44	1
II	106	0.988[0.364, 2.679]	0.981
III	135	1.203[0.318, 4.550]	0.785
IV	32	2.785[0.652, 11.898]	0.167
Family history of stomach cancer
Yes	15	1
No	243	0.946[0.541, 1.655]	0.845
N/A	59	0.833[0.316, 2.196]	0.712
H. pylori infection
Yes	17	1
No	129	0.983[0.583, 1.657]	0.949
N/A	171	0.576[0.214, 1.550]	0.275
Grade
G1	8	1
G2	108	2.529[0.322,19.847]	0.377
G3	193	3.226[0.418, 24.870]	0.261
GX	8	4.065[0.378, 43.697]	0.247
Reflux history
Yes	35	1
No	158	0.972[0.567, 1.665]	0.917
N/A	124	0.561[0.231, 1.364]	0.202
Disease type
Adenomas and adenocarcinomas	289	1
Cystic, mucinous and serous Neoplasms	28	0.615[0.301, 1.256]	0.182
Risk
High	158	1		1
Low	159	0.525[0.354, 0.780]	0.001	0.538[0.379, 0.765]	< 0.001

ISSN: 1479-5876