Fig. 2

Construction and analysis of the circadian rhythm score model. A Flow chart of CRS model construction. B Univariate cox regression analysis of CRGs in cancer. C Distribution of CRS values in organs. D Percentage of samples with CRS-high and CRS-low classifications across 18 cancer types based on the optimal threshold of CRS as the cutoff. E Difference of CRS between tumor samples and adjacent normal samples and CRS subgroups across 18 cancer types. F Differences in survival time and clinical characteristics among CRS subgroups. G Survival analysis of GEO validation data. H Heat map of CRGs expression. I Bar-compartmental plots of CRS in experimental and control groups. J The rhythm of CRS over time in four validated datasets