MiR-200/183 family-mediated module biomarker for gastric cancer progression: an AI-assisted bioinformatics method with experimental functional survey

Yan, Wenying; Chen, Yuqi; Hu, Guang; Shi, Tongguo; Liu, Xingyi; Li, Juntao; Sun, Linqing; Qian, Fuliang; Chen, Weichang

doi:10.1186/s12967-023-04010-z

Table 3 Association of mRNAs in miR-200/183 family-mediated module with clinic pathological characteristics of GC patients from TCGA

From: MiR-200/183 family-mediated module biomarker for gastric cancer progression: an AI-assisted bioinformatics method with experimental functional survey

Characteristics	Total	BNC2			GIT2			LDB3			NOVA1			NPTX1			NR3C1			SWAP70			WIPF1			ZEB2
Characteristics	Total	High	Low	p	High	Low	p	High	Low	p	High	Low	p	High	Low	p	High	Low	p	High	Low	p	High	Low	p	High	Low	p
Age
≤ 60	89	37	52	0.003*	51	38	0.004*	22	67	0.076	33	56	0.005*	31	58	0.000*	48	41	0.034*	35	54	0.964	50	39	0.003*	42	47	0.119
> 60	168	39	129		63	105		25	143		34	134		24	144		66	102		68	100		61	107		61	107
Gender
Female	99	29	70	1.000	46	53	0.682	20	79	0.644	28	71	0.622	23	76	0.681	44	55	1.000	42	57	0.633	45	54	0.652	42	57	0.633
Male	158	47	111		68	90		27	131		39	119		32	126		70	88		61	97		66	92		61	97
TNM stage
I	35	3	32	0.025*	9	26	0.023*	1	34	0.047*	3	32	0.042*	2	33	0.084	6	29	0.003*	9	26	0.071	8	27	0.050	7	28	0.023*
II	94	28	66		38	56		16	78		24	70		20	74		41	53		33	61		40	54		35	59
III	103	36	67		52	51		24	79		34	69		27	76		55	48		49	54		51	52		48	55
IV	25	9	16		15	10		6	19		6	19		6	19		12	13		12	13		12	13		13	12
T
T1	10	0	10	0.011*	2	8	0.002*	0	10	0.008*	0	10	0.044	0	10	0.028*	1	9	0.005*	3	7	0.028*	1	9	0.004*	2	8	0.005*
T2	64	13	51		21	43		4	60		11	53		8	56		20	44		16	48		21	43		19	45
T3	106	32	74		44	62		24	82		32	74		24	82		52	54		49	57		45	61		39	67
T4	77	31	46		47	30		19	58		24	53		23	54		41	36		35	42		44	33		43	34
N
N0	87	19	68	0.101	32	55	0.329	12	75	0.200	16	71	0.079	17	70	0.965	25	62	0.005*	27	60	0.150	35	52	0.853	29	58	0.196
N1	75	22	53		34	41		12	63		21	54		17	58		39	36		33	42		32	43		29	46
N2	44	13	31		23	21		8	36		10	34		9	35		22	22		22	22		19	25		18	26
N3	50	21	29		24	26		14	36		19	31		11	39		27	23		21	29		24	26		26	24
M
M0	230	68	162	0.558	102	128	0.075	44	186	0.276	61	169	0.823	52	178	0.196	101	129	0.543	88	142	0.150	101	129	0.206	92	138	0.140
M1	16	6	10		10	6		3	13		4	12		3	13		9	7		10	6		8	8		9	7
Mx	11	2	9		2	9		0	11		2	9		0	11		4	7		5	6		2	9		2	9
Type
Diffuse	49	28	21	0.000*	32	17	0.002*	14	35	0.087	24	25	0.000*	15	34	0.167	30	19	0.007*	26	23	0.114	30	19	0.003*	32	17	0.000*
Intestinal	89	13	76		30	59		12	77		12	77		15	74		30	59		34	55		28	61		25	64
Others	119	35	84		52	67		21	98		31	88		25	94		54	65		43	76		53	66		46	73
Grade
G1	3	1	2	0.000*	1	2	0.000*	1	2	0.000*	1	2	0.001*	2	1	0.000*	1	2	0.001*	1	2	0.061	1	2	0.001*	1	2	0.000*
G2	79	7	72		16	63		3	76		8	71		5	74		20	59		22	57		19	60		13	66
G3	170	65	105		94	76		40	130		55	115		46	124		90	80		78	92		88	82		86	84
Gx	5	3	2		3	2		3	2		3	2		2	3		3	2		2	3		3	2		3	2

T: primary tumor invasion depth; N: lymph node metastasis; M: distant metastasis
^*p-value < 0.05

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