Fig. 3

The miR-200/183 family-mediated module is key module in GC progression. a Expression of miR-200 and miR-183 families in GC tissues with four TNM stages. b The miR-200/183 family-mediated module for GC progression. Pink and blue denote up and down regulation, respectively, in LSGC samples. c Expression of nine mRNAs in GC tissues with four TNM stages. d Kaplan–Meier analysis was used to estimate the survival of high-risk vs. low-risk patients with GC according to the seven miRNA signatures from the miR-200 and miR-183 families in the training set. e Kaplan–Meier analysis was used to estimate the survival of high-risk vs. low-risk patients with GC according to the seven miRNA signatures from the miR-200 and miR-183 families in the validation cohort. (*p-value < 0.05, **p-value < 0.01, ***p-value < 0.001)