Fig. 4
From: Abnormal signal pathways and tumor heterogeneity in osteosarcoma
Transcriptomic heterogeneity of oncocytes in OS. A Re-clustering of OS oncocytes. B The copy number variation (CNV) was estimated using inferCNV (with myogenic cells as a reference) to distinguish oncocytes and normal cells. The red and blue colors represent the copy number variation. C The CNV score of each cell was calculated as a quadraic sum of CNV. D A heat map shows the hub genes in each sub-cluster. E Kaplan–Meier survival curve shows the survival of OS patients with high- and low risk-scores for each subcluster signature (Nhigh-risk = 27 vs. Nlow-risk = 26)