Fig. 2

Schematic diagram of ncRNAs regulating periodontium remodeling during OTM. PDL, located between alveolar bone and cementum, is a fibrous connective tissue with neurovascularity and heterogeneous cell groups. A ncRNAs contribute to sensing and transducing mechanical forces in osteocytes and PDLCs. B In the catabolic phase, ncRNAs are involved in osteoclast-mediated bone resorption and PDLC-mediated PDL degradation. C In the subsequent anabolic stage, ncRNAs regulate the function of osteoblasts and PDL synthesis. D ncRNAs are responsible for coordinating delicate communication via cytokines or intercellular contact