Fig. 6From: Sirt3 restricts tumor initiation via promoting LONP1 deacetylation and K63 ubiquitinationLONP1 K145 acetylation controls tumor growth. A–D K145Q mutation supported tumor growth. LONP1 WT, K145Q, K145R mutation and vector SW480 cells were subcutaneously injected into BALB/c mouse. After 21 days, the mice were sacrificed. Tumor weight and volume were measured B, C. The ATP level was detected using ATP detection kit DBack to article page