Fig. 1

Conditional Sirt3 knockout augments adenoma number and size in APC^Min/+ mice. A Tumor-bearing intestine from AVS (APC^Min/+-villin-CRE-sirt3^fl/fl) and APC^Min/+ mice were dissected and dyed with methylene blue. B, C AVS suffer more colorectal adenoma compare to APC^Min/+. The number and diameter of adenoma was calculated respectively. D, WB analysis of LONP1, Sirt3, β-catenin and PCNA expression in adenoma from AVS and APC^Min/+ mice. E, IHC images of COX2 and PCNA expression in adenoma. F, G IHC scores showing higher expression of COX2 and PCNA in AVS. H, I Information analysis of expression of sirt3 and LONP1 in patient with colon cancer, respectively