High proportion of circulating CD8 + CD28- senescent T cells is an independent predictor of distant metastasis in nasopharyngeal carcinoma after radiotherapy

Table 1 Characteristics of the patients

Variable		Training (131)	%	Validation (162)		P
Sex	1	105	80.2	127	78.4	0.713
	2	26	19.8	35	21.6
Age	Median	48		47		0.611
	Range	21–80		15–73
EBV	Undetectable	54	41.2	37	22.8	0.003
	< 1500 copies/ml	53	40.5	91	56.2
	> 1500 copies/ml	24	18.3	34	21
Posttreatment EBV	Undetectable	128	97.7	149	92	0.032
	Detectable	3	2.3	13	8
T	T1	13	9.9	11	6.8	0.582
	T2	16	12.2	26	16
	T3	73	55.7	85	52.5
	T4	29	22.1	40	24.7
N	N0	12	9.2	5	3.1	0.008
	N1	49	37.4	41	25.3
	N2	47	35.7	80	49.4
	N3	23	17.6	36	22.2
Stage	I	1	0.8	2	1.2	0.243
	II	15	11.5	11	6.8
	III	72	55	80	49.4
	IV	43	32.8	69	42.6

ISSN: 1479-5876