Table 1 lncRNAs associated with BC
LncRNA/ID (ensemble/NCBI) | Dysregulation of lncRNA (promote/inhibit) | Oncogene/tumor suppressor | Effect on BC | References |
|---|---|---|---|---|
AC026904.1 (LINC02599)/ENSG00000233858 | Upregulation/promote | Oncogene | Metastasis, EMT | [111] |
AFAP1-AS1/ENSG00000272620 | Upregulation/promote | Oncogene | Chemoresistance, proliferation, migration, invasion | [112] |
ANCR/ENSG00000226950 | Upregulation/inhibit | Tumor suppressor | Invasion, metastasis, migration, EMT | [113] |
DANCR/ENSG00000226950 | Upregulation/promote | Oncogene | Proliferation, invasion, tumor growth | [114] |
ARNILA/ENSG00000235072 | Upregulation/promote | Oncogene | Progression-free survival, EMT, invasion, metastasis | [115] |
ATB (LNCRNA-ATB)/Gene ID: 114004396 | Upregulation/promote | Oncogene | EMT, drug resistance, anti-apoptosis, proliferation, invasion, metastasis | [116] |
BC200 (BCYRN1)/ENSG00000236824 | Upregulation/promote | Oncogene | Proliferation, migration, invasion, tumor size | [117] |
BCAR4/ENSG00000262117 | Upregulation/promote | Oncogene | Migration, invasion, metastasis | [118] |
BDNF-AS/ENSG00000245573 | Upregulation/promote | Oncogene | Prognostic predictor for poor survival, proliferation, endocrine resistance, progression | [119] |
BLACAT1/ENSG00000281406 | Upregulation/promote | Oncogene | Migration, invasion, metastasis, cell survival, proliferation | [120] |
BORG | Upregulation/promote | Oncogene | Invasion, metastasis, disease recurrence | [121] |
CASC2/ENSG00000177640 | Upregulation/inhibit | Tumor suppressor | Proliferation, metastasis, cell cycle arrest, apoptosis, migration | [122] |
CCAT1/Gene ID: 100507056 | Upregulation/promote | Oncogene | Cell proliferation, migration, invasion, tumor growth, progression | [123] |
CCAT2/ENSG00000280997 | Upregulation/promote | Oncogene | Migration, invasion, metastasis, cancer growth, cell cycle, apoptosis, proliferation | [124] |
EPIC1/ENSG00000224271 | Upregulation/promote | Oncogene | Cell cycle, progression, prognosis, tumor growth | [125] |
ES1 (LINC01108)/ENSG00000226673 | Upregulation/promote | Oncogene | Stemness, proliferation, cell cycle progression, apoptosis, migration, EMT | [126] |
EZR-AS1/ENSG00000233893 | Upregulation/promote | Oncogene | Tumor growth, metastasis, prognosis, proliferation, cell cycle progression, apoptosis, migration, invasion | [127] |
FEZF1-AS1/ENSG00000230316 | Upregulation/promote | Oncogene | Stemness, tumorigenesis, proliferation, migration, invasion, cells growth | [128] |
FGF13-AS1/ENSG00000226031 | Upregulation/inhibit | Tumor suppressor | Stemness, proliferation, migration, invasion, prognosis | [129] |
GACAT3/ENSG00000236289 | Upregulation/promote | Oncogene | Prognosis, preoperative MRI perfusion-related diffusion reduction and elevated perfusion fraction | [130] |
GAS5/ENSG00000234741 | Upregulation/inhibit | Tumor suppressor | Metastasis, proliferation, drug resistance | [131] |
GHET1/ENSG00000281189 | Upregulation/promote | Oncogene | Proliferation, invasion, migration, apoptosis, EMT | [132] |
H19/ENSG00000130600 | Upregulation/promote | Oncogene | Proliferation, invasion, migration, cell cycle arrest, apoptosis, metastasis | [133] |
HIF1A-AS2/Gene ID: 100750247 | Upregulation/promote | Oncogene | Prognosis, migration, invasion, overall survival | [134] |
HOST2 (CERNA2)/ENSG00000285972 | Upregulation/promote | Oncogene | Cell motility, migration, invasion | [135] |
HOTAIR/ENSG00000228630 | Upregulation/promote | Oncogene | Proliferation, invasion, EMT, metastasis, drug resistance | [136] |
ITGB2-AS1/ENSG00000227039 | Upregulation/promote | Oncogene | Migration, invasion | [137] |
LET | Upregulation/inhibit | Tumor suppressor | Proliferation, invasion, migration, apoptosis | [138] |
LIMT (LINC01089)/ENSG00000212694 | Downregulation/promote | Tumor suppressor | Migration, invasion, metastasis, prognosis | [139] |
LINC00115/ENSG00000225880 | Upregulation/promote | Oncogene | Metastasis, migration, invasion | [140] |
LINC00152 (CYTOR)/ENSG00000222041 | Upregulation/promote | Oncogene | Invasion, migration, tumorigenesis, colony growth, tumor growth, apoptosis | [141] |
LINC00461/ENSG00000245526 | Upregulation/promote | Oncogene | Invasion, migration, differentiation | [142] |
LINC00511/Gene ID: 400619 | Upregulation/promote | Oncogene | Proliferation, invasion, stemness, tumourigenesis | [143] |
LINC00628/ENSG00000280924 | Upregulation/inhibit | Tumor suppressor | Proliferation, invasion, migration, cell growth, metastasis, apoptosis | [144] |
LINC00673/Gene ID: 100499467 | Upregulation/promote | Oncogene | Proliferation, metastasis | [145] |
LINC00899/ENSG00000231711 | Upregulation/inhibit | Tumor suppressor | Proliferation, migration, invasion, progression | [146] |
LINC01133/ENSG00000224259 | Upregulation/inhibit | Tumor suppressor | Migration, invasion, metastasis | [147] |
LINC01296 (DUXAP9)/ENSG00000225210 | Upregulation/promote | Oncogene | Proliferation, prognosis, metastasis, apoptosis | [148] |
LINC01787/ENSG00000231987 | Upregulation/promote | Oncogene | Proliferation, migration | [149] |
LINC01857/ENSG00000224137 | Upregulation/promote | Oncogene | Invasion, migration | [150] |
LincIN | Downregulation/inhibit | Oncogene | Migration, invasion, metastasis | [151] |
Linc-ITGB1 (IATPR)/ENSG00000233387 | Upregulation/promote | Oncogene | Invasion, migration, proliferation | [152] |
Linc-ROR/ENSG00000258609 | Upregulation/promote | Oncogene | Tumorigenesis, migration, invasion, metastasis, growth | [153] |
LINP1/ENSG00000223784 | Upregulation/promote | Oncogene | Apoptosis, mobility, EMT, drug resistance, migration, invasion, tumor growth | [154] |
Lnc015192 | Upregulation/promote | Oncogene | Migration, invasion, EMT, metastasis | [155] |
Lnc01638/ENSG00000233521 | Upregulation/promote | Oncogene | Proliferation, tumor growth, invasion, colonization, metastasis | [156] |
Lnc-BM | Upregulation/promote | Oncogene | Metastasis | [157] |
LncKLHDC7B/ENSG00000226738 | Downregulation/promote | Tumor suppressor | Invasion, migration, apoptosis | [158] |
LncRNA 91H | Upregulation/promote | Oncogene | Cell growth, migration, invasion, tumor growth | [159] |
lncRNA HIT | Upregulation/promote | Oncogene | Migration, invasion, tumor growth, metastasis, EMT | [160] |
LncRNA RP1/ENST00000420172 | Upregulation/promote | Oncogene | Prognosis, proliferation, metastasis, EMT, stemness | [161] |
LncRNA-ATB/Gene ID: 114004396 | Upregulation/promote | Oncogene | Drug resistance, invasion-metastasis cascade | [162] |
lncRNA-Hh (GAS1RR)/ENSG00000226237 | Upregulation/promote | Oncogene | Tumorigenesis | [163] |
Lnc-SLC4A1-1 | Downregulation/inhibit | Oncogene | Apoptosis, proliferation, migration, invasion | [164] |
MAGI2-AS3/ENSG00000234456 | Upregulation/inhibit | Tumor suppressor | Cell growth, proliferation, cell viability, colony formation, apoptosis | [165] |
MALAT1/ENSG00000251562 | Upregulation/inhibit | Tumor suppressor | Migration, invasion | [166] |
Upregulation/promote | Oncogene | |||
Migration, progression, proliferation, differentiation, metastasis | [167] | |||
MAYA (MNX1-AS1)/ENSG00000243479 | Upregulation/promote | Oncogene | EMT, proliferation, migration, invasion | [168] |
MEG3/ENSG00000214548 | Upregulation/inhibit | Tumor suppressor | Proliferation, Migration, Invasion, Apoptosis | [169] |
MIR100HG/ENSG00000255248 | Upregulation/promote | Oncogene | Proliferation, cell arrest in the G1 | [170] |
MT1JP/ENSG00000255986 | Upregulation/inhibit | Tumor suppressor | Proliferation, invasion, drug sensitivity | [171] |
NBAT1/ENSG00000260455 | Upregulation/inhibit | Tumor suppressor | Migration, invasion, metastasis, prognosis | [172] |
NEAT1/ENSG00000245532 | Upregulation/promote | Oncogene | Tumor size, prognosis, proliferation, metastasis, EMT | [173] |
LncRNA NEF (LNCNEF)/ENSG00000237396 | Upregulation/inhibit | Tumor suppressor | Invasion, migration | [174] |
NKILA/ENSG00000278709 | Upregulation/inhibit | Tumor suppressor | EMT, metastasis | [175] |
NLIPMT/ENSG00000278709 | Upregulation/inhibit | Tumor suppressor | Proliferation, motility, progression | [176] |
NNT-AS1/ENSG00000248092 | Upregulation/promote | Oncogene | Migration, invasion, progression, EMT, proliferation | [177] |
NORAD/ENSG00000260032 | Downregulation/promote | Tumor suppressor | Migration, invasion, metastasis | [178] |
P10247 (lncRNA-BCHE)/ENSG00000114200 | Upregulation/promote | Oncogene | Metastasis, growth, migration, invasion | [179] |
PDCD4-AS1/ENSG00000203497 | Upregulation/inhibit | Tumor suppressor | Progression | [180] |
PRLB (SIRLNT)/ENSG00000253802 | Upregulation/promote | Oncogene | Proliferation, chemoresistance, metastasis, survival, invasion | [181] |
PTENP1/ENSG00000237984 | Upregulation/inhibit | Tumor suppressor | Proliferation, invasion, tumorigenesis, tumor growth, metastasis, apoptosis, chemoresistance | [182] |
PVT1/ENSG00000249859 | Upregulation/promote | Oncogene | Proliferation, colony formation, tumor growth | [183] |
PITPNA-AS1/ENSG00000236618 | Downregulation/inhibit | Oncogene | Cell viability, proliferation, migration, invasion | [184] |
SPRY4-IT1/GeneID:100642175 | Upregulation/promote | Oncogene | Proliferation, migration, invasion, cell cycle, apoptosis | [185] |
SUMO1P3/ENSG00000235082 | Downregulation/inhibit | Oncogene | Progression, survival, proliferation, migration, invasion | [186] |
TFAP2A-AS1/ENSG00000229950 | Upregulation/inhibit | Tumor suppressor | Invasion, migration, proliferation, cell cycle arrest, apoptosis, ability, tumor growth | [187] |
TINCR/ENSG00000223573 | Upregulation/promote | Oncogene | Migration, invasion, tumor growth, proliferation, apoptosis | [188] |
TUG1/ENSG00000253352 | Downregulation/promote | Tumor suppressor | Apoptosis, proliferation, metastasis, invasion | [189] |
Downregulation/inhibit | Oncogene | Proliferation, metastasis, tumor size, TNM staging, migration, invasion, apoptosis | [190] | |
TUNAR/ENSG00000250366 | Upregulation/promote | Oncogene | Stemness, motility, invasion, EMT | [191] |
UCA1/ENSG00000214049 | Upregulation/promote | Oncogene | Apoptosis, drug resistance | [192] |
XIST/ENSG00000229807 | Downregulation/promote | Tumor suppressor | Cell growth, migration, invasion | [193] |
LINC02095(ROCR)/ENSG00000228639 | Upregulation/promote | Oncogene | Proliferation | [194] |
WT1-AS/ENSG00000183242 | Upregulation/inhibit | Tumor suppressor | Clinical stages, migration, invasion | [195] |
LINC00096(TP53TG1)/ENSG00000182165 | Upregulation/promote | Oncogene | Proliferation, invasion, metastasis | [196] |
HEIH/ENSG00000278970 | Downregulation/inhibit | Oncogene | Proliferation, apoptosis | [197] |
LUCAT1/ENSG00000248323 | Upregulation/promote | Oncogene | Proliferation, cell cycle progression, metastasis, apoptosis | [198] |
ASRPS(LINC00908)/ENSG00000266256 | Downregulation/promote | Tumor suppressor | Angiogenesis, tumor growth | [199] |
HAND2-AS1/ENSG00000237125 | Upregulation/inhibit | Tumor suppressor | Proliferation | [200] |
LINC01096/ENSG00000246095 | Downregulation/inhibit | Oncogene | Proliferation, migration, invasion; apoptosis, cell viability | [201] |
PANDA(PANDAR)/ENSG00000281450 | Upregulation/promote | Oncogene | Apoptosis | [202] |
TP73-AS1/ENSG00000227372 | Upregulation/promote | Oncogene | Proliferation, invasion, migration | [203] |
CRNDE/ENSG00000245694 | Upregulation/promote | Oncogene | Proliferation, migration, invasion | [204] |
HCP5/ENSG00000206337 | Downregulation/promote | Tumor suppressor | Drug resistance | [205] |
ADAMTS9-AS2/ENSG00000241684 | Downregulation/promote | Tumor suppressor | Drug resistance, apoptosis, viability | [206] |
TMPO-AS1/ENSG00000257167 | Upregulation/promote | Oncogene | Proliferation, viability, apoptosis, drug resistance | [207] |
DSCAM-AS1/ENSG00000235123 | Downregulation/inhibit | Oncogene | Proliferation, colony formation | [208] |
MAFG-AS1(MILIP)/ENSG00000265688 | Downregulation/inhibit | Oncogene | Proliferation, apoptosis, drug resistance | [209] |
DILA1(MIR99AHG)/ENSG00000215386 | Upregulation/promote | Oncogene | Drug resistance, proliferation, prognosis, tumor growth | [210] |
DLX6-AS1/ENSG00000231764 | Upregulation/promote | Oncogene | Apoptosis, migration, drug resistance, EMT | [211] |
SNHG7/ENSG00000233016 | Upregulation/promote | Oncogene | Viability, drug resistance | [212] |
DCST1-AS1/ENSG00000232093 | Upregulation/promote | Oncogene | Drug resistance, EMT, chemoresistance | [213] |
LINC00472/ENSG00000233237 | Downregulation/promote | Tumor suppressor | Growth, aggressiveness | [214] |
AGAP2-AS1/ENSG00000255737 | Upregulation/promote | Oncogene | Tumor growth, apoptosis, chemoresistance, drug resistance | [215] |
SNHG14/ENSG00000224078 | Upregulation/promote | Oncogene | Proliferation, invasion, drug resistance | [216] |
MAPT-AS1/ENSG00000264589 | Downregulation/inhibit | Oncogene | Drug resistance, migration, invasion, proliferation | [217] |
Linc00518/ENSG00000183674 | Upregulation/promote | Oncogene | Drug resistance | [218] |
FTH1P3/ENSG00000213453 | Downregulation/inhibit | Oncogene | Drug resistance | [219] |
FGF14-AS2/ENSG00000272143 | Downregulation/promote | Tumor suppressor | Progression, prognosis, tumor size, lymph node metastasis, clinical stage, overall survival | [220] |
PAPAS | Upregulation/promote | Oncogene | Migration, invasion | [221] |
lncMat2B | Upregulation/promote | Oncogene | Drug resistance | [222] |
LOL | Downregulation/inhibit | Oncogene | Apoptosis, proliferation, drug resistance | [223] |
BC032585 | Downregulation/promote | Tumor suppressor | Drug resistance | [224] |
NONHSAT101069 | Upregulation/promote | Oncogene | Drug sensitivity, metastasis, migration, invasion | [225] |
DRHC | Downregulation/promote | Tumor suppressor | Proliferation | [226] |