Impact of total cerebral small vessel disease score on ophthalmic artery morphologies and hemodynamics

Table 2 The univariate linear regression analysis and multivariate stepwise regression analysis between clinical characteristics and OA diameter and blood flow velocity

		Univariate		Multivariate^a
	Variables	β (95% CI)	P Value^*	β(95% CI)	P Value
Diameter	SBP	− 0.007 (− 0.011 to − 0.003)	0.001
	Homocysteine	− 0.016 (− 0.030 to − 0.002)	0.025
	WMHs	− 0.223 (− 0.375 to − 0.072)	0.005
	CMB	− 0.263 (− 0.408 to − 0.118)	0.001	− 0.231 (− 0.380 to − 0.082)	0.003
	Enlarged perivascular spaces	− 0.245 (− 0.400 to − 0.090)	0.003	− 0.226 (− 0.382 to − 0.071)	0.006
Velocity^b	Ischemic heart disease	− 0.529 (− 0.840 to − 0.219)	0.001	− 0.318 (− 0.539 to − 0.097)	0.006
	Lacunar infarct	− 0.663 (− 0.936 to − 0.391)	< 0.001	− 0.424 (− 0.648 to − 0.200)	< 0.001
	WMHs	− 0.709 (− 0.959 to − 0.459)	< 0.001	− 0.468 (− 0.692 to − 0.245)	< 0.001
	CMB	− 0.621 (− 0.892 to − 0.350)	< 0.001

SBP systolic blood pressure, WMHs white matter hyperintensities, CMB cerebral microbleed
^*P < 0.05 is significant in univariate linear regression analysis
^aSignificant variables in results of the univariate regression were included in the multivariate stepwise regression analysis
^bVariables are transformed to natural logarithms

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