Fig. 6

The miR-148/152 family members suppress the tumorigenesis of gastric cancer stem cells in vivo. A The volume of xenotransplanted tumors in nude mice treated with miR-148a mimic, miR-148b mimic, and/or miR-152 mimic at the indicated time points. B Representative images showing xenografts in nude mice treated with miR-148a mimic, miR-148b mimic, and/or miR-152 mimic. C The weight of xenotransplanted tumors in nude mice treated with miR-148a mimic, miR-148b mimic, and/or miR-152 mimic. D ITGA5 expression in tissues derived from subcutaneous xenotransplanted tumors in nude mice treated with miR-148a mimic, miR-148b mimic, and/or miR-152 mimic measured by RT-qPCR. E Immunohistochemical staining of ITGA5 protein in tissues derived from subcutaneous xenotransplanted tumors in nude mice treated with miR-148a mimic, miR-148b mimic, and/or miR-152 mimic (scale bar: 25 μm). F Correlation of miR-148a, miR-148b, and miR-152 expression with ITGA5 expression in tissues derived from subcutaneous xenotransplanted tumors in nude mice analyzed by Pearson’s correlation coefficient. *p < 0.05 compared with mimic-NC