Fig. 5

A Differences in TMB between the HHSG and LHSG. B The correlation between HS and TMB. C Differences in stromal, immune, and ESTIMATE scores between the HHSG and LHSG (^nsP > 0.05, ***P < 0.001). D, E The top 20 driver genes with the highest mutation frequency in the (D) HHSG and E LHSG. F Differences in OS between the TMB subgroups. G–J OS differences stratified by TMB and HS, H stromal scores and HS, I immune scores and HS, and J ESTIMATE scores and HS. TMB tumor mutation burden, HHSG high hypoxia score group, LHSG low hypoxia score group, OS overall survival, HS hypoxia score