Plasma GAS6 predicts mortality risk in acute heart failure patients: insights from the DRAGON-HF trial

Table 3 Associations between biomarkers and prognostic discrimination

Model	C-index	NRI	P value	IDI	P value
All-cause death
Clinical model	0.74	Reference		Reference
+ GAS6	0.77	0.04 (0.02,0.07)	< 0.001	0.05 (0.01,0.23)	0.03
+ NT-proBNP	0.78	0.08 (0.04,0.11)	< 0.001	0.37 (0.24,0.43)	< 0.001
+ CRP	0.74	0 (0,0.01)	0.909	0.1 (0.12,0.19)	0.37
+ TnT	0.76	0.03 (0.01,0.06)	0.01	0.24 (0.11,0.34)	0.01
NT-proBNP + GAS6 + TnT + CRP	0.80	0.11 (0.07,0.16)	< 0.001	0.35 (0.21,0.45)	< 0.001
Cardiovascular death
Clinical model	0.74	Reference		Reference
+ GAS6	0.77	0.04 (0.01,0.08)	< 0.001	0.07 (0,0.26)	0.046
+ NT-proBNP	0.80	0.08 (0.04,0.12)	< 0.001	0.34 (0.25,0.46)	< 0.001
+ CRP	0.75	0 (0,0.02)	0.9	0.11 (0.14,0.22)	0.44
+ TnT	0.77	0.02 (0,0.07)	0.01	0.24 (0.09,0.36)	0.01
NT-proBNP + TnT + CRP + GAS6	0.82	0.11 (0.07,0.18)	< 0.001	0.38 (0.26,0.49)	< 0.001

IDI: integrated discrimination improvement; NRI: net reclassification index; other abbreviations as shown in Table 1
Clinical model includes: age, sex, BMI, smoking, hypertension, diabetes, atrial fibrillation, eGFR

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