Fig. 6

CCCs influences clinical prognosis and immunotherapy efficacy. A Unsupervised classification uncovers two clusters (Cluster A, Cluster B), depending on the fractions of myeloid cells, T cells and HLR-tumor cells calculated by CIBERSORTx of TCGA-KIRC cohort, the boxed section is the fraction of HLR tumor. B Kaplan–Meier plot demonstrates that ccRCC patients in Cluster B had a longer survival than Cluster A. C The fraction of immune cells is compared in Cluster A and Cluster B, *p < 0.05; **p < 0.01; ***p < 0.001; NS, not significant. D–E Box diagrams exhibited the correlation of stromal and immune calculated by ESTIMATE algorithm with clusters. F Patients in Cluster A have lower TMB levels than those in Cluster B. G Two clusters (Cluster 1 and Cluster 2) of David A. Braun, et al. cohort were identified by CIBERSORTx algorithm. H Kaplan–Meier curves of the OS for the Cluster A and Cluster B