Table 2 Univariate and multivariate analyses of factors associated with overall survival
From: Prognostic value of genetic aberrations and tumor immune microenvironment in primary acral melanoma
Factor | Variable | Univariate analysis | Multivariate analysis | |||
|---|---|---|---|---|---|---|
HR (95% CI) | p value | HR (95% CI) | p value | |||
Age |  ≥ 62 vs. < 62 | 3.13(1.54–6.39) |  < 0.01 | 2.77 (1.22, 6.28) | 0.02 | |
Gender | Male vs. female | 1.67(0.83–3.35) | 0.15 |  |  | |
Clinical stage | III&IV vs. I&II | 2.26(1.17–4.39) | 0.01 | 2.57 (1.25, 5.29) | 0.01 | |
Pathological type | NM&ALM vs. other types | 3.64(1.11–11.90) | 0.02 | 3.98 (0.88, 17.97) | 0.07 | |
Breslow thickness |  > 4.0 vs. ≤ 4.0 | 4.73(2.18–10.30) |  < 0.01 | 3.43 (1.51, 7.82) |  < 0.01 | |
Primary site | Hand vs. Foot | 0.18(0.02–1.31) | 0.06 |  |  | |
Ulceration status | With vs. Without | 1.58(0.76–3.28) | 0.22 |  |  | |
Treatment | Yes vs. No | 0.34(0.18–0.66) |  < 0.01 | 0.36 (0.17, 0.76) | 0.01 | |
Mutation status | RAS/RAF/KITm vs. RAS/RAF/KITw | 0.77(0.39–1.51) | 0.44 |  |  | |