Fig. 2

Case 1. Probability of pharmacological success (PoPS) for two compounds against neurodegeneration—Compound A (left) and Compound B (right). Upper panels: proportion of patients with sufficient central inhibition and peripheral preservation (solid curves), and proportion of patients with insufficient peripheral preservation (dashed curves); the lines are the medians of simulations; the bands reflect the 90% predictive intervals of simulations. Lower panels: PoPS of the two compounds