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Fig. 4 | Journal of Translational Medicine

Fig. 4

From: Papillary thyroid cancer organoids harboring BRAFV600E mutation reveal potentially beneficial effects of BRAF inhibitor-based combination therapies

Fig. 4

Genetic characterization of PTC tissues and the derived organoids. a Heatmap analysis of the somatic mutated cancer genes in PTC organoids with those in parental tumors. b Heatmap displaying the mutational signature contributions of organoids and respective tumors. c Histogram showing the proportions of base substitutions in the paired tumor tissues and organoids. d Representative gene copy number variations of the paired PTC organoids and tumor tissues. Passage numbers of PTC organoid lines were: PTC-1_O, P3; PTC-2_O, P4; PTC-4_O, P4; PTC-5_O, P5; PTC-6_O, P3; PTC-7_O, P5; PTC-8_O, P4

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Journal of Translational Medicine

ISSN: 1479-5876

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