Genome-wide associated variants of subclinical atherosclerosis among young people with HIV and gene-environment interactions

Table 5 The significant gene-set analyses for cIMT among participants under 45 years old

Category	GeneSet	N	n	P-value	Adjusted P	Genes
PWH under 45 years old
GO_bp	regulation of atrial cardiac muscle cell membrane repolarization	8	2	4.75E−06	0.034	KCNQ1, SCN5A
GO_bp	atrial cardiac muscle cell membrane repolarization	11	2	9.33E−06	0.034	KCNQ1, SCN5A
GO_mf	protein kinase A catalytic subunit binding	13	2	1.32E−05	0.018	KCNQ1, PJA2
GO_mf	protein kinase A regulatory subunit binding	20	2	3.22E−05	0.018	KCNQ1, PJA2
GO_mf	protein phosphatase 1 binding	20	2	3.22E−05	0.018	KCNQ1, FER
GO_mf	protein kinase activity	588	4	9.15E−05	0.038	DCLK3, ACVR2B, EPHA6, FER
HIV-negative participants under 45 years old
GWAS catalog reported genes	Hyperopia	6	2	1.09E−06	1.98E−03	RBFOX1, LAMA2
GWAS catalog reported genes	Urinary albumin-to-creatinine ratio in non-diabetics	19	2	1.24E−05	6.44E−03	SOGA3, SOGA3, C6orf58
GWAS catalog reported genes	Spherical equivalent (joint analysis main effects and education interaction)	20	2	1.38E−05	6.44E−03	RBFOX1, LAMA2
GWAS catalog reported genes	Spherical equivalent or myopia (age of diagnosis)	175	3	1.42E−05	6.44E−03	RBFOX1, LAMA2, DPP6
GWAS catalog reported genes	Refractive error	29	2	2.95E−05	1.07E−02	RBFOX1, LAMA2
GWAS catalog reported genes	Waist-to-hip ratio adjusted for BMI	403	3	1.69E−04	4.30E−02	ECHDC1, SOGA3, SOGA3, C6orf58
GWAS catalog reported genes	Intracranial aneurysm	72	2	1.84E−04	4.30E−02	RBFOX1, CARHSP1
GWAS catalog reported genes	Myopia	73	2	1.89E−04	4.30E−02	RBFOX1, LAMA2

Results of gene-set analyses for cIMT among PWH and HIV-negative counterparts under 45 years old. Gene-set analysis used the results from genes mapped in SNP-based analysis as input. N: Genes in Gene Set; n: Genes in Overlap.GO: gene ontology

ISSN: 1479-5876