Table 4 Association of SNP × traditional risk factors with cIMT among PWH
CHR | SNP | Position (GRCh37) | MAF | Gene | Location | Minor allele | SNP × covariate | SNP | Covariate | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
β valuea | P interaction | β valuea | P value | β valuea | P value | |||||||
SNP × alcohol interaction |  |  |  |  |  |  |  |  |  |  |  | |
6 | rs9375288 | 124,194,087 | 0.123 | NKAIN2 | Intronic | G | 0.09 | 2.31E−08 | 0.03 | 8.10E−02 | 0.01 | 7.70E−01 |
12 | rs77741796 | 80,815,650 | 0.054 | PTPRQ | Intergenic | T | 0.10 | 6.45E−06 | 0.03 | 2.31E−01 | − 0.01 | 7.68E−01 |
3 | rs6762348 | 96,683,649 | 0.058 | EPHA6 | Intronic | G | 0.10 | 2.23E−05 | − 0.01 | 7.37E−01 | − 0.01 | 8.61E–01 |
3 | rs62262941 | 96,570,987 | 0.057 | EPHA6 | Intronic | C | 0.10 | 3.40E−05 | − 0.01 | 8.26E−01 | − 0.01 | 8.90E−01 |
3 | rs62263680 | 96,627,491 | 0.057 | EPHA6 | Intronic | C | 0.10 | 3.83E−05 | − 0.01 | 8.22E−01 | − 0.01 | 8.81E−01 |
4 | rs148420952 | 171,482,271 | 0.051 | LINC01612 | Intergenic | T | 0.09 | 1.74E−04 | 0.01 | 9.23E−01 | − 0.01 | 8.86E−01 |
12 | rs10847321 | 127,782,099 | 0.056 | LINC02376 | Intergenic | A | 0.05 | 1.97E−02 | 0.01 | 9.53E−01 | 0.01 | 8.51E−01 |
SNP × tobacco interaction |  |  |  |  |  |  |  |  |  |  |  | |
9 | rs817856 | 110,118,754 | 0.115 | RAD23B | Intergenic | G | 0.39 | 1.03E−09 | − 0.02 | 2.15E−01 | − 0.04 | 1.81E−01 |
8 | rs78096022 | 132,359,092 | 0.107 | ADCY8 | Intergenic | T | 0.41 | 3.70E−09 | − 0.03 | 4.55E−02 | − 0.04 | 2.58E−01 |
20 | rs6513469 | 58,588,895 | 0.059 | CDH26 | 3′-UTR | C | 0.50 | 9.53E−09 | 0.01 | 7.63E−01 | − 0.03 | 3.73E−01 |
1 | rs17392147 | 9,060,210 | 0.054 | SLC2A7 | Intronic | C | 0.83 | 1.89E−08 | 0.02 | 4.43E−01 | 0.01 | 9.39E−01 |
5 | rs186333 | 23,202,461 | 0.074 | CDH12 | Intergenic | G | 0.43 | 2.70E−08 | − 0.01 | 6.68E−01 | − 0.02 | 5.47E−01 |
5 | rs78752139 | 103,593,227 | 0.092 | NUDT12 | Intergenic | T | 0.40 | 4.28E−08 | − 0.01 | 9.25E−01 | − 0.04 | 2.88E−01 |
11 | rs111815403 | 2,553,341 | 0.061 | KCNQ1 | Intronic | A | 0.22 | 3.67E−03 | 0.04 | 2.64E−02 | 0.01 | 8.74E−01 |
4 | rs148420952 | 171,482,271 | 0.051 | LINC01612 | Intergenic | T | − 0.24 | 1.39E−02 | 0.08 | 1.64E−04 | 0.06 | 4.87E−02 |
3 | rs2507941 | 37,536,056 | 0.064 | ITGA9 | Synonymous | T | 0.30 | 1.79E−02 | 0.05 | 7.73E−03 | 0.03 | 4.29E−01 |
SNP × BMI category interaction |  |  |  |  |  |  |  |  |  |  |  | |
3 | rs2507941 | 37,536,056 | 0.064 | ITGA9 | Synonymous | T | 0.12 | 1.87E−04 | − 0.21 | 5.03E−03 | 0.01 | 5.19E−01 |
12 | rs10847321 | 127,782,099 | 0.056 | LINC02376 | Intergenic | A | 0.11 | 1.48E−03 | − 0.20 | 1.01E−02 | 0.01 | 3.62E−01 |
11 | rs111815403 | 2,553,341 | 0.061 | KCNQ1 | Intronic | A | 0.10 | 2.91E−03 | − 0.16 | 3.41E−02 | 0.01 | 3.77E−01 |
4 | rs148420952 | 171,482,271 | 0.051 | LINC01612 | Intergenic | T | 0.08 | 1.69E−02 | − 0.11 | 1.50E−01 | 0.01 | 2.86E−01 |
5 | rs35812497 | 108,563,812 | 0.089 | FER, PJA2 | Intergenic | A | 0.06 | 3.58E−02 | − 0.09 | 1.46E−01 | 0.01 | 3.63E−01 |
3 | rs6762348 | 96,683,649 | 0.058 | EPHA6 | Intronic | G | 0.06 | 4.18E−02 | − 0.09 | 2.20E−01 | 0.01 | 2.24E−01 |