Fig. 4

NOG is a target gene of METTL3-mediated m⁶A modification. A The top terms identified by Gene Ontology enrichment analysis of overlapping DEGs in METTL3-knockdown OM-DPSCs after induction for both 7 and 14 days. B Scatter plots of the top items in Gene Ontology enrichment. C The enrichment analysis of KEGG pathways. D The differentially m⁶A methylated and expressed genes in the m⁶A-mRNA profile after induction for 7 and 14 days by m⁶A RIP & RNA sequencing. E Venn diagram showing overlapping genes between DEGs in transcriptome sequencing after METTL3 knockdown and m⁶A-methylated transcripts during DPSC mineralization. DEGs: differentially expressed genes; D(m⁶A)MGs: differentially m⁶A methylated genes