Table 3 Preclinical studies of CD47 BsAb in solid tumors
From: Targeting macrophages: a novel treatment strategy in solid tumors
Targets | Type of diseases | References |
|---|---|---|
CD47/GPC3 | HCC | [156] |
CD47/EGFR | EGFR + tumors | [157] |
SIRPα/VEGFR1 | NSCLC, Glioblastoma | |
CD47/MSLN | MSLN + tumors | [159] |
SIRPα/CD40L | Solid tumors (mouse CT26 tumor model) | [160] |
SIRPα/CTLA4 | Solid tumors | [161] |
CD47/DLL3 | SCLC Neuroendocrine cancers | [162] |
Claudin18.2/CD47 | gastric cancer Gastroesophageal junction (GEJ) cancer Pancreatic cancer | [163] |