Fig. 8

Effects of TPP-MR on myocardial injury in sepsis. A Cardiac function including echocardiograms (n = 6/group), B cardiac EF (n = 6/group) and C cardiac output (n = 8/group) were measured 2 h after resuscitation treatment. D The malic acid content in heart tissue were measured 2 h after resuscitation treatment, n = 6/group. E–F The effects of TPP-MR on survival rate and survival time of septic rats (n = 8/group). G HE stains of cardiac tissue and H heart injury score (bar, 100 µm, n = 6/group). I–K ATP and OCR detection in NRCMs (3 independent experiments). L The mitochondrial membrane potential of NRCMs (bar, 30 µm, 3 independent experiments). M ROS content in NRCMs (bar, 50 µm, 3 independent experiments). a: P < 0.05 compared with the sham or normal group, b: P < 0.05 compared with the sepsis or LPS group, c: P < 0.05 compared with the LR group