Fig. 4

Assessment of 4 field HLA-typing accuracy from lc-WGS. a, b Number of concordant HLA alleles (0: white, 1: grey:, 2: black) between haplotypes from the clinical gold standard and those imputed using QUILT-HLA for class I (A, B, C) and class II (DQB1 and DRB1) HLA genes (rows) using a blood DNA of 14 patients or b tissue DNA of 10 patients (columns). c Fraction of HLA alleles correctly imputed (y-axis), versus the sample source of the DNA (x-axis), colored by the HLA gene. d Imputation posterior probability from QUILT-HLA for each HLA gene (color) and sample (dot), compared between samples with perfect HLA-gene concordance (both alleles match) versus those with errors