Fig. 4

Mediation analysis for glucose, PWA PP and SBP—the effects and confidence intervals. A Glucose, B PWA PP, C SBP. Taxa correlating with glucose or PWA PP or SBP (FDR P < 0.1, Fig. 3C) are shown. Marked red taxa with FDR P < 0.05 (Fig. 3C). ACME average causal mediation effect, ADE average direct effect, TE total effect. Significance of each effect can be deduced from 95% confidence intervals not containing 0