Fig. 2

Balloon plot of the association of microbial fecal metabolites, microbial pathway and plasma metabolites with all 19 health outcomes. LDL cholesterol is included as positive control. Non-available (NA) associations stem from a lack of overlapping SNPs or proxies between exposure and outcome data resulting in fewer than three genetic instruments in the harmonized data set. Associations at P-value  > 0.05 are depicted with crosses. For readability, the effect of LDL on LDL was forced to be non-available