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Table 1 Demographics and clinical characteristics of the patients for developing the prediction model

From: Development of a risk prediction model for bloodstream infection in patients with fever of unknown origin

Characteristic

Total

Bloodstream infection

P value

Yes

No

Number of patients

712

55

657

NA

Demographics

 Age, median (IQR), yrs

52 (33–65)

56 (38–66)

52 (33–65)

0.201

 Male sex

364 (51.1)

29 (52.7)

335 (51.0)

0.804

Final diagnosis

 Infectious disease

366 (51.4)

55 (100)

311 (47.3)

NA

 NIID

203 (28.5)

NA

203 (30.9)

NA

 Malignanciesa

52 (7.3)

NA

52 (7.9)

NA

 Other and unknown

91 (12.8)

NA

91 (13.9)

NA

Comorbidity

 Diabetes mellitus

72 (10.1)

17 (30.9)

55 (8.4)

0.000

 Liver cirrhosis

12 (1.7)

4 (7.3)

8 (1.2)

0.001

 Chronic kidney disease

14 (2.0)

3 (5.5)

11 (1.7)

0.062

 Solid tumor

24 (3.4)

7 (12.7)

17 (2.6)

0.001

 Hematological malignancy

7 (1.0)

1 (1.8)

6 (0.9)

0.432

Other underlying condition

 Corticosteroid useb

17 (2.4)

3 (5.5)

14 (2.1)

0.137

 Chemotherapyb

9 (1.3)

2 (3.6)

7 (1.1)

0.149

 Invasive procedureb

63 (8.8)

9 (16.4)

54 (8.2)

0.049

 Catheter use

15 (2.1)

4 (7.3)

11 (1.7)

0.023

 Implant device

12 (1.7)

4 (7.3)

8 (1.2)

0.010

Clinical feature

 Highest temperature, median (IQR), ℃

39.2 (38.8–39.9)

39.5 (39.0–40.0)

39.2 (38.8–39.8)

0.004

 Chills

208 (29.2)

32 (58.2)

176 (26.8)

0.000

Outcome

 In-hospital mortality

0 (0)

0 (0)

0 (0)

NA

 LOS, median (IQR), d

11 (7–17)

14 (10–21)

11 (7–17)

0.004

  1. Data are presented as n (%) unless otherwise indicated
  2. IQR interquartile range, LOS length of stay, NA not applicable/available; NIID non-infectious inflammatory disease
  3. aTumor-related fever should meet all the following conditions: there is no evidence of infection based on physical examination, laboratory (including sterile body fluid smear and culture) and imaging examination. Antibiotic treatment did not reduce the highest body temperature. The highest body temperature was really reduced after treatment with non-steroidal anti-inflammatory drugs. Otherwise, the tumor is regarded as a comorbidity rather than a cause of fever
  4. bWithin 30 days before admission