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Table 4 Over-representation of GO biological processes amongst upregulated proteins in OVCAR5 CBPR cells

From: Platinum-resistance in epithelial ovarian cancer: an interplay of epithelial–mesenchymal transition interlinked with reprogrammed metabolism

GO term

Biological processes (GO)a

Count in gene set

False Discovery Rate

GO: 0030155

Regulation of cell adhesion

6 of 623

0.0049

GO:0065008

Regulation of biological quality

11 of 2559

0.0133

GO: 0051128

Regulation of cellular component organization

9 of 2306

0.0133

GO: 0033627

Cell adhesion mediated by integrin

2 of 17

0.0133

GO: 0032879

Regulation of localization

9 of 2524

0.0133

GO: 0030198

Extracellular matrix organization

4 of 296

0.0133

GO: 0007160

Cell–matrix adhesion

3 of 1194

0.0138

GO: 0009653

Anatomical structure morphogenesis

8 of 1992

0.0144

GO: 0000902

Cell morphogenesis

5 of 626

0.0144

GO: 0030154

Cell differentiation

10 of 3457

0.0149

GO: 0045785

Positive regulation of cell adhesion

4 of 375

0.0151

GO: 0040011

Locomotion

6 of 1144

0.0163

GO: 0007166

Cell surface receptor signaling pathway

8 of 2198

0.0163

GO: 0010810

Regulation of cell-substrate adhesion

3 of 189

0.0182

GO: 1900024

Regulation of substrate adhesion-dependent cell spreading

2 of 47

0.0197

GO: 0000904

Cell morphogenesis involved in differentiation

4 of 498

0.0197

GO: 0010769

Regulation of cell morphogenesis involved in differentiation

3 of 263

0.0275

GO: 0030334

Regulation of cell migration

4 of 753

0.0492

  1. aGO enrichment analysis using the Homo sapiens gene database was performed on genes which encode the 18 upregulated proteins identified in the OVCAR5 CBPR cells. GO identifier, description of the biological processes and false discovery rate are listed. “Count in gene” set refers to the number of genes in our dataset that are mapped to the total number of genes in the respective category