Fig. 6

Paxlovid accelerates subchondral bone sclerosis and osteophytes formation in vivo. A A timeline of mouse experiments and their related interventions, created with BioRender.com B Strategy of subchondral bone reconstruction. The red line is perpendicular to the articular surface and passes through the midpoint of the medial tibial plateau. C Representative images of sagittal planes of subchondral bones and osteophytes in different treatment groups. Scale bar: 500 μm. D Quantitative analysis of micro-computed tomography scans: BV/TV, percent bone volume; Tb.N, trabecular number; Tb.Th, trabecular thickness; Tb.Sp, trabecular separation. N = 6, 6, 5, and 6 biologically independent joint samples of the Sham, Paxlovid, DMM, and DMM + Paxlovid groups, respectively. *P < 0.05, **P < 0.01, ***P < 0.001, and ****P < 0.0001