Fig. 1
From: Integration of CRISPR/Cas9 with artificial intelligence for improved cancer therapeutics
CRISPR/Cas9 in cancer research. A Schematic diagram illustrating cancer initiation and progression by involvement of multiple genetic and epigenetic alterations in cancer. B Different approaches used for genome editing in cancer include ZFNs, TALENs, and CRISPR/Cas9 systems. C CRISPR/Cas9 editing targets specific genes or growth factors regulating oncogenic processes. D Numerous mutations and dysregulated expression of oncogenes, tumor suppressor genes, chemotherapy-resistant genes, and cancer stem cell–related genes involved in tumorigenesis targeted by CRISPR/Cas9 system can be used for discovery of novel biomarkers and therapeutic targets in cancer research