Fig. 2

A Schematic scheme of disturbed metabolic pathways. Metabolites marked in green and yellow indicate metabolites concentration comparison between nonobese MAFLD with vs without CAS, and obese MAFLD with vs without CAS, respectively. ItaE, low specificity l-threonine aldolase; glyA, glycine hydroxy methyltransferase; CBS, cystathionine beta-synthase; metH, MTR, 5-methyltetrahydrofolate–homocysteine methyltransferase; ALT, alanine transaminase.PAH, proclavaminate amidinohydrolase; OTC, ornithine carbamoyltransferase; GlnA, glutamine synthetase; XDH, xanthine dehydrogenase/oxidase; ETNK, ethanolamine kinase. B LASSO regression analysis of factors associated with carotid atherosclerosis among nonobese MAFLD and obese MAFLD patients, respectively. Each curve corresponds to an index. C Mass spectrograms of metabolites with top 10 VIP value based on the partial least squares-discriminant analysis (PLS-DA). D The diagram of metabolites for KEGG pathway enrichment analysis among all MAFLD, nonobese MAFLD and obese MAFLD, respectively