Table 2 Genetic loci identified by the four measures of CIPN exceeding suggestive and genome-wide significance
From: Polygenic risk of paclitaxel-induced peripheral neuropathy: a genome-wide association study
Chromosome | Base position | SNP | Beta | P-Value | CIPN Measure |
|---|---|---|---|---|---|
3 | 31064705 | rs9846958 | 48.83 | 8.81E−11* | Patient-reported CIPN (EORTC QLQ-CIPN20) |
18 | 75143190 | rs117158921 | 27.44 | 6.65E−09 * | |
4 | 41447510 | rs4560447 | 73.28 | 2.60E−08 * | |
10 | 26947753 | rs200091415 | 73.28 | 2.60E−08 * | |
1 | 4314360 | rs16841032 | 34.79 | 1.86E−07 | |
11 | 115,685,183 | rs116038987 | 30.96 | 2.37E−07 | |
2 | 67726417 | rs79369145 | 28.28 | 2.54E−07 | |
13 | 72495513 | rs150199484 | 22.06 | 2.93E−07 | |
17 | 43935838 | rs2301689 | 8.405 | 3.81E−07 | |
3 | 31028952 | rs1395163 | 33.93 | 3.89E−07 | |
19 | 55,896,795 | rs3810167 | 14.01 | 6.83E−07 | |
17 | 17246862 | rs60566375 | 20.2 | 9.84E−07 | |
4 | 40232733 | rs115791832 | 20.94 | 1.24E−06 | |
17 | 75540158 | rs73997920 | 45.74 | 1.24E−06 | |
10 | 97171050 | rs11818044 | 26.71 | 1.25E−06 | |
10 | 97174537 | rs7081076 | 26.71 | 1.25E−06 | |
10 | 97189291 | rs76700761 | 26.71 | 1.25E−06 | |
1 | 4338586 | rs75263049 | 29.1 | 1.33E−06 | |
16 | 74334369 | rs118029597 | 32.16 | 1.66E−06 | |
9 | 24971701 | rs117703887 | 20.41 | 1.82E−06 | |
1 | 239257873 | rs74973152 | 21.46 | 2.36E−06 | |
10 | 17449757 | rs12248657 | 36.51 | 2.37E−06 | |
3 | 184475364 | rs4686398 | 44.55 | 2.42E−06 | |
15 | 40126543 | rs275760 | 31.67 | 2.45E−06 | |
15 | 40143910 | rs275729 | 31.67 | 2.45E−06 | |
11 | 252649 | rs6540 | 19.47 | 2.51E−06 | |
11 | 258397 | rs474787 | 19.47 | 2.51E−06 | |
11 | 127101270 | rs117097754 | 44.46 | 2.54E−06 | |
4 | 157936227 | rs77573336 | 28.35 | 2.57E−06 | |
4 | 69706215 | rs62300681 | 31.36 | 3.10E−06 | |
11 | 122641495 | rs4936743 | 17.25 | 3.17E−06 | |
11 | 211482 | rs2293168 | 16.22 | 3.25E−06 | |
11 | 211841 | rs75256197 | 16.22 | 3.25E−06 | |
11 | 130309871 | rs111669817 | 25.6 | 3.58E−06 | |
6 | 22118002 | rs114044180 | 31.04 | 3.98E−06 | |
18 | 1375378 | rs111376654 | 19.95 | 4.12E−06 | |
11 | 82568940 | rs12294147 | 20.89 | 4.73E−06 | |
15 | 25520032 | rs117465857 | 30.75 | 4.94E−06 | |
6 | 75965294 | rs45596238 | 23.44 | 4.98E−06 | |
11 | 134945120 | rs77234116 | 35.36 | 5.09E−06 | |
2 | 182965672 | rs16822577 | 23.36 | 5.40E−06 | |
7 | 19,868,985 | rs117016159 | 25.2 | 5.41E−06 | |
19 | 24217139 | rs117117437 | 20.71 | 5.46E−06 | |
19 | 28225540 | rs117635212 | 20.71 | 5.46E−06 | |
9 | 7036643 | rs117691749 | 23.4 | 5.48E−06 | |
1 | 22346009 | rs2501296 | 21.81 | 6.00E−06 | |
1 | 168472921 | rs7536740 | 16.05 | 6.34E−06 | |
12 | 111254708 | rs117378411 | 27.25 | 6.54E−06 | |
3 | 118337935 | rs77999651 | 17.92 | 6.85E−06 | |
9 | 27336982 | rs74621663 | 17.26 | 6.89E−06 | |
14 | 37217129 | rs8021974 | 12.66 | 7.62E−06 | |
4 | 38725705 | rs728169 | 26.98 | 8.14E−06 | |
4 | 41372088 | rs116183417 | 18.49 | 8.37E−06 | |
10 | 101214126 | rs77000635 | 26.89 | 8.76E−06 | |
6 | 24445829 | rs9358767 | 1.777 | 2.56E−06 | Neurological grading (TNSc) |
13 | 22776823 | rs61945320 | 3.59 | 2.89E−06 | |
17 | 7931282 | rs7217076 | 2.778 | 5.74E−06 | |
1 | 87930889 | rs6683030 | 1.077 | 9.93E−06 | |
13 | 103476981 | rs80322894 | −0.4543 | 4.61E−06 | Clinical grading (NCI CTCAE) |
7 | 48093679 | rs10254800 | −0.1962 | 4.65E−06 | |
19 | 56169604 | rs3786648 | −0.2651 | 6.88E−06 | |
4 | 2058475 | rs382939 | −0.3386 | 7.99E−06 | |
5 | 99023153 | rs115135785 | −0.3333 | 8.68E−06 | |
1 | 153317515 | rs41308407 | −0.7946 | 8.80E−06 |