Evaluating the frequency and the impact of pharmacogenetic alleles in an ancestrally diverse Biobank population

Table 4 Top 10 drugs by number of PMBB participants with PGx actionable alleles. Proportion of participants prescribed a medication also carrying an actionable allele for that drug. The count of prescribed drugs with actionable alleles (ACT), total prescribed drugs considered (TOT), and proportion of prescribed drugs with actionable alleles (PROP) are shown

Drug	Genes	Proportion of Total Prescribed with Actionable PGx
		EUR			AFR			EAS			SAS			AMR			UNKNOWN			TOTAL
		ACT	TOT	PROP	ACT	TOT	PROP	ACT	TOT	PROP	ACT	TOT	PROP	ACT	TOT	PROP	ACT	TOT	PROP	ACT	TOT	PROP
warfarin	CYP2C9 CYP4F2 VKORC1 rs12777823	1904	2216	0.8592	416	864	0.4815	19	20	0.9500	15	18	0.8333	19	22	0.8636	23	26	0.8846	2396	3166	0.7568
clopidogrel	CYP2C19	537	1988	0.2701	276	753	0.3665	10	18	0.5556	20	34	0.5882	3	25	0.1200	10	19	0.5263	856	2837	0.3017
tacrolimus	CYP3A5	214	1494	0.1432	409	585	0.6991	15	23	0.6522	7	27	0.2593	17	39	0.4359	1	24	0.0417	663	2192	0.3025
simvastatin	SLCO1B1	507	1806	0.2807	94	994	0.0946	11	28	0.3929	3	24	0.1250	3	27	0.1111	7	23	0.3043	625	2902	0.2154
amitriptyline	CYP2C19 (CYP2D6 not used)	219	511	0.4286	196	522	0.3755	0	7	0.0000	3	4	0.7500	2	15	0.1333	4	9	0.4444	424	1068	0.3970
omeprazole	CYP2C19	237	4780	0.0496	149	3177	0.0469	0	79	0.0000	6	105	0.0571	3	121	0.0248	2	63	0.0317	397	8325	0.0477
ibuprofen	CYP2C9	76	4178	0.0182	110	4137	0.0266	0	150	0.0000	0	116	0.0000	1	148	0.0068	3	113	0.0265	190	8842	0.0215
escitalopram	CYP2C19	115	1619	0.0710	53	648	0.0818	4	20	0.2000	3	16	0.1875	1	33	0.0303	1	12	0.0833	177	2348	0.0754
voriconazole	CYP2C19	140	247	0.5668	24	34	0.7059	1	1	1.0000	3	5	0.6000	3	5	0.6000	0	3	0.0000	171	295	0.5797
lansoprazole	CYP2C19	93	1890	0.0492	58	1086	0.0534	0	26	0.0000	0	31	0.0000	1	34	0.0294	1	28	0.0357	153	3095	0.0494

ISSN: 1479-5876