Fig. 5
From: Potential therapeutic strategies for photoreceptor degeneration: the path to restore vision
visual cycle pathway. Schematic representation of the phototransduction cascade and the visual cycle. In the left, the outer segment of PR was surrounded by the microvilli of the RPE apical membrane. In close, the biochemical events of RPE/ PR interaction have been presented. Upon light absorption by 11-cis-retinal opsin (inactive rhodopsin), the 11-cis- retinal rapidly is photo-isomerized to all-trans-retinal to form activated rhodopsin which in turn activates the heterotrimeric G-protein transducin and initiates the downstream signaling