Fig. 7
From: DNA methylation predicts the outcome of COVID-19 patients with acute respiratory distress syndrome
Summary of immune cells and methylation changes over four time points in COVID-19 patients. A. Spline regression plot of neutrophile changes over four time points in dead (red color) vs. recovered patients (blue color). B. Spline regression plot of significant CpGs (cg00237825) over four time points in recovered vs. dead patients for DEFB115 C. Spline regression plot of significant CpGs (cg13700506) over four time points in recovered vs. dead patients for DEFB116. Spline plots show the spline regression model fitted to the four time points neutrophile proportion data (A) and methylation (B). The blue line represents the fitted model for the recovered, while the red line represents dead patients. Blue and red dots represent the proportion of neutrophils/methylation of the biological replicates for dead and recovered patients. Vertical lines are the endpoints and interior knots representing 0.33 and 0.66 quantiles