Fig. 3

Go term enrichment for the differentially expressed proteins between CD8⁺ T cells from young and old donors. The STRING output is organized in several categories: Biological process (A), Molecular function (B), Reactome pathways (C), KEGG pathways (D) and UniProt keywords (E). Each GO term has XZ coordinates corresponding to the inverse of the False Discovery Rate (FDR), which describes the statistical significance, and the observed gene count, which represents the number of proteins from the input, which are annotated with the respective GO term. A dotted line is placed at x = 2 which corresponds to an FDR of 0.01, when necessary. The terms with the lowest FDR are colored red. F Cellular compartment distribution. The Venn diagram represents the GO terms found by STRING for the Cellular Component category. The proportions of each compartment are calculated with Venny 2.0