Fig. 2
From: Anthocyanin improves kidney function in diabetic kidney disease by regulating amino acid metabolism
Effect of ANT on the protein expression profile in the kidney of db/db mice. (A) The heatmap of the expression of proteins in the kidney in the CT, DKD, and ANT groups. The expression of each protein was normalized. Volcano plots showing the differentially expressed proteins between the DKD vs. CT (B) and ANT vs. DKD (C) groups. (D) Renal proteomic profiles after STEM analysis. STEM analysis was applied to obtain the protein expression profiles across the CT, DKD, and ANT groups. Profile ID is shown at the top left corner of the profile. Lines in each profile represent the expression pattern of proteins across the three groups (permutation test, P < 0.05). (E) Venn diagram summarizing the differential and overlapping proteins among the DKD vs. CT groups, ANT vs. DKD groups, and STEM_trend (FC > 1.5 or FC < 0.67, unpaired two-sided student’s t-tests, P < 0.05). (F) Heatmap of the expression of ANT kidney trend proteins. (G) The function analysis of ANT kidney trend proteins in Metascape platform (P < 0.01)