Fig. 5

Inflamed TME in high Rad-TILs revealed by transcriptomics analysis. A Comparison of immune cell subpopulation between high and low Rad-TILs. The p values were calculated using Wilcoxon test. Specific p values were denoted on each cell type. B, C Expression of immune-related signatures in high and low Rad-TILs. Cytolytic activity (B) and T cell inflamed gene expression profiles (GEPs) (C) of two groups. The p values were calculated using Wilcoxon test. D, J Distinct expression of immune-related molecules on cell surface, including costimulators (D), coinhibitors (E) and major histocompatibility complex (J) between two groups. Distinct immune-related secretary molecules, including interleukins (F), chemokines (G), interferons (H) and colony-stimulating factors (I) between two groups. The p values calculated by Wilcoxon test were adjusted to false discovery rate (FDR) using the Benjamini–Hochberg procedure in multiple comparisons. Specific FDR values were denoted on each molecule