Fig. 3

Strength and pathways involved in cell–cell interactions from four different states. A The incoming and outgoing strength of each immune cell under health, hepatitis, cirrhosis, and cancer, respectively. The communication probability of pathways from B health to hepatitis, C hepatitis to cirrhosis, and D cirrhosis to cancer. The difference in communication probability of ligand-receptor interactions from (E health to hepatitis, F hepatitis to cirrhosis, and G cirrhosis to cancer. Note: B–G is limited to the interaction of macrophages (sender) and naïve CD4 + T cells (receiver)