Fig. 7From: Loss of endothelial EMCN drives tumor lung metastasis through the premetastatic nicheA proposed working model. The loss of endothelial EMCN caused an increase in vascular permeability, produced a premetastatic niche and promoted tumor lung metastasis. Downregulation of EMCN expression was reversed by treatment with a Notch inhibitor combined with an anti-TGF-β antibody to inhibit lung metastasisBack to article page