Fig. 5

11β-HSD1 knockdown attenuated hippocampal neuronal damage and inhibited hippocampal apoptosis in the PTZ-induced epilepsy mice. A Representative micrographs (original magnification, × 400) of Nissl staining show that 11β-HSD1 knockdown alleviated hippocampal neuronal damage induced by PTZ kindling in CA1 and DG. B–D Western blot images show BCL-2, BAX and Cleaved Caspase-3 proteins expression (*P < 0.05, epilepsy group vs control group, Con-shRNA group vs 11β-HSD1-shRNA group). The bars indicated the mean ± SD